Short answer: it can be possible, but only with careful screening. With Crohn’s disease and infliximab, the key factors are disease stability, recent infections or surgeries, and your overall resilience. Evidence on psilocybin in people with Crohn’s who use TNF inhibitors is limited, so I cannot verify individual safety.
There are no clinical trials confirming that psilocybin is safe or beneficial specifically for Crohn’s. I also cannot verify a direct interaction with infliximab. A medical review by your treating physician plus a thorough intake with the facilitator is essential before considering a session.
About alprazolam: it can blunt psychedelic effects and is sometimes kept on hand to reduce intensity if needed. Do not stop it abruptly if you use it regularly. Any change should be discussed with your prescriber.
If your Crohn’s is stable, your doctor has no objections, and you complete proper preparation and integration, an individual session might be considered. You can arrange a one-on-one intake and discuss your medications via this individual session. I hope this helps you weigh your options safely.