Yes. A recent double-blind, randomized, placebo-controlled crossover study in 23 healthy participants directly compared equimolar doses of MDMA and MDA and found that MDA produced stronger and longer-lasting acute effects than MDMA, with more adverse and psychedelic-like effects (study).
On average, the subjective drug effect lasted about 6.1 hours with MDA versus 4.1 hours with MDMA. MDA induced more stimulant effects, more negative or unpleasant effects, more fear, and more visual alterations. Pharmacokinetics aligned with this pattern, with plasma half-lives of roughly 8.4 hours for MDA and 7.3 hours for MDMA.
Lysine-MDA acted as a slow-release prodrug, delaying onset and peak while producing otherwise similar effects to MDA. Lysine-MDMA did not release MDMA detectably and produced no corresponding acute effects.
These findings come from healthy volunteers in a controlled setting and describe acute responses, not clinical outcomes. Within those limits, MDA appears stronger, longer-lasting, and more adverse than MDMA at equimolar doses.
Hope this clarifies the comparison.