Short answer: there is no reliable evidence that psilocybin in a skincare cream can slow or reverse cellular aging, and I cannot verify such claims. Human data are lacking, and the idea faces basic pharmacology and formulation hurdles.
Psilocybin is a prodrug that is mainly converted to its active form in the gut and liver. The skin has limited capacity for this conversion, psilocine is chemically unstable, and its penetration through the skin barrier is poor, so a topical product is unlikely to reach meaningful cellular targets.
Early cell and animal findings suggest possible pathway effects, but these do not establish safe or effective topical use in people, and any benefits proposed are likely systemic rather than local. Legal status and safety considerations also apply.
Future skincare may focus on stable molecules that target similar cellular pathways without psychedelics. For a concise overview of why a psilocybin cream is unlikely to work, see this discussion.
Bottom line: a psilocybin cream is not a realistic anti-aging option at this time.