There is no universal “better” choice, but for therapy MDMA is generally the better-supported option because it has the most clinical research and a more predictable profile. 5-MAPB has far less study data, variable sourcing, and unknown long-term risks, so it is more experimental.
Subjectively, many describe MDMA as pro-social and talk-friendly, while some report 5-MAPB as calmer with more inward focus. I cannot verify consistency of effects, purity, or safety outside regulated settings, and individual responses vary.
If you proceed, prioritize legality, qualified support, screening, and careful integration. For a short perspective on choosing compounds for therapeutic aims, see this Q&A.
Stay safe and thoughtful.