Short answer: there is not yet solid human evidence that psilocybin or ergothioneine support healthy aging. Early findings suggest psilocybin may influence neuroplasticity, and ergothioneine may act as a cell-protective antioxidant, but these ideas remain exploratory and unproven for aging outcomes.
Much of the research cited comes from cell or animal models, with small or short human studies. I cannot verify the specific study identifiers mentioned, and there are no large, long-term trials showing improvements in telomeres, lifespan, or broad aging measures.
Practical note: psilocybin is a controlled substance in many regions and should only be considered in legal, supervised settings. Ergothioneine occurs naturally in mushrooms and supplements, yet optimal intake and long-term effects for aging are unclear. Prioritize well-supported basics like sleep, physical activity, nutrition, stress management, and social connection.
For a background discussion on theoretical links between psilocybin, stress, and telomeres, see this overview: psilocybin and telomere protection.
In short, promising ideas, not proven strategies.