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Which is better for OCD, psilocybin or LSD?

There is no clear winner for OCD. Evidence is limited, and I cannot verify that psilocybin or LSD is superior overall. In practice, many therapists start with psilocybin because it has a larger research footprint in OCD and a shorter duration, which can make sessions easier to structure. LSD lasts longer and some people report […]

Does psilocybin or psilocin increase bioavailable tryptophan via kynurenine?

Short answer: possibly, but not proven. Psilocybin converts to psilocin, which in cell models can modulate immune signaling through 5‑HT2A receptors. That could indirectly affect how tryptophan is used. Under stress and inflammation, IDO and TDO enzymes divert tryptophan into the kynurenine pathway, sometimes called a tryptophan steal. If psilocin reduces pro‑inflammatory cytokines, IDO/TDO activity […]

Should I switch from sertraline during SIBO or IMO treatment?

Short answer: do not switch or stop sertraline for SIBO or IMO unless your prescriber advises it. Many people are treated for SIBO or IMO while staying on an SSRI. Evidence about a direct link between SSRIs and SIBO is not definitive, and I cannot verify the specific studies you mentioned. If your clinicians believe […]

What are the best movies to watch while tripping on shrooms or LSD?

The best movies for shrooms or LSD usually pair rich, beautiful visuals with clear storytelling, steady pacing, and an uplifting tone. Avoid horror and very frantic editing if you are sensitive to intensity. Great picks include Interstellar for cosmic awe and an enveloping score, Inception for lucid-dream spectacle, Soul for warm color and music, and […]

Do you offer a psilocybin retreat in the Netherlands, and what does it include?

Yes. We host psilocybin retreats in the Netherlands that include guided psilocybin truffle ceremonies. You can also choose the psiloflora option at no extra cost. Sessions are available for individuals or small groups. Retreats include healthy meals, overnight accommodation, a preparation call, the ceremony itself, and an integration call afterward. Prices start from 600 euros, […]

How do I book a tripsitter?

Start by completing the intake form at this page. Your answers help the team review your request and confirm the next steps. After the intake is approved, you can book a session. Check tripsitter availability, choose who you want to work with, and select a date and location that suits you. If you already submitted […]

Does microdosing work better than a placebo?

Short answer: in blinded, controlled studies, microdosing has not consistently outperformed placebo. Expectation and placebo effects likely explain a large share of reported benefits. On mechanisms: tryptophan has limited brain uptake, while psilocin from psilocybin crosses the blood brain barrier more easily. Psilocin and serotonin share MAO-driven breakdown routes. There is no solid evidence that […]

What happens in the brain during a psilocybin truffle ceremony?

During a psilocybin truffle ceremony, psilocybin is converted to psilocin, which activates serotonin 5-HT2A receptors in the cortex. Brain imaging studies in humans often show reduced cohesion within the default mode network and increased communication between networks, creating a more flexible, less predictable activity pattern that can correlate with a softened sense of self. Research […]

Should I choose a group truffle ceremony or a private session in Delft?

Both a group truffle ceremony and a private session in Delft can be suitable. The better choice depends on your comfort with privacy, your goals, and how you feel about sharing space with others. Choose a group if you value connection, shared energy, and learning from peers. Look for small groups, clear facilitation, and options […]

Which is safer and simpler, psilohuasca or a high-dose truffle ceremony?

For most people, a high-dose truffle ceremony without MAO inhibitors is the simpler and often safer choice. It is more predictable and avoids extra variables that can complicate the experience. Psilocybin in truffles is already orally active, so no MAOI is needed. Skipping MAOIs means no special diet and fewer concerns about interactions. If you […]