Short answer: there is no strong evidence that psilocybin truffles inherently work differently in women. Individual responses vary a lot, and sex-specific research is limited.
What can differ is the context. Cycle-related factors like PMS can bring irritability, fatigue, low mood, concentration issues, and poor sleep, which may shape the experience even if the chemistry is the same. Many people prefer to schedule a session outside the days when these symptoms are strongest.
In preparation, focus on basics like rest, nutrition, and calm surroundings. Some consider vitamin B1 to support PMS-related mood and energy based on a small study, but this is not definitive and I cannot verify its effects for you. The aim is not to boost truffles, but to support stability beforehand.
If you want a concise overview of timing and preparation considerations for women, see this Q&A: Do psilocybin truffles work differently in women?
Hope this helps. Stay mindful and prepared.