MDMA and psilocybin tend to play different roles in couples therapy. MDMA is often used to support connection, empathy, and open communication. Many report it reduces defensiveness and helps partners discuss difficult topics with more warmth and trust.
Psilocybin is more associated with deep personal introspection. It can help individuals notice patterns, beliefs, and unresolved feelings that spill into the relationship, which may set the stage for healthier engagement with a partner.
Some facilitators combine them: first an individual psilocybin session for self-insight, then a joint MDMA session focused on vulnerability, listening, and repair. You can read more about one structured approach here: Relationship therapy with MDMA or psilocybin.
Suitability depends on your goals, health, and local laws. Work with qualified professionals, and be aware that outcomes vary. I cannot verify results for any specific couple.
Hope this comparison helps you choose what fits your needs.