Short answer: it can be done, but both mirtazapine and lorazepam may blunt a psilocybin experience. Mirtazapine is associated with reduced intensity, fewer visuals, and less emotional depth. Lorazepam can lower anxiety and tension, yet may also flatten insights and feelings. Neither guarantees a “safe” or “better” session, and I cannot verify your personal risk.
Whether this is reasonable for you depends on dose, how long you have used these meds, how often you take them, and why they were prescribed. Do not stop or change medication just to amplify a session without guidance, since withdrawal or symptom return can complicate things.
If you are considering a session, discuss your plan with your prescribing clinician and arrange a proper intake and preparation. A structured approach to psilocybin therapy helps assess interactions and set expectations.
Take care and prioritize safety first.