Short answer: in a small randomized pilot study, psilocybin given once within a structured cognitive behavioral therapy program was reported to yield higher quit rates at 6 months than nicotine patches paired with the same therapy. Biochemically confirmed prolonged abstinence was about 40 percent for psilocybin versus about 10 percent for patches, with similar advantages on 7-day point prevalence. I cannot independently verify the 2026 publication details, so view this as preliminary.
Important caveats: it was a pilot, unblinded, with a specific sample, and the psilocybin group had more total contact time, which could add nonspecific benefits. Results need replication in larger, diverse, well-controlled trials. For a readable summary of the study and context, see this article: psilocybin vs nicotine patches for smoking cessation.
Bottom line: early data suggest psilocybin-assisted therapy may outperform nicotine patches within this study design, but it is not definitive evidence and does not replace established cessation supports. If you are considering options, discuss evidence, legality, and safety with a qualified professional.
Hope this helps.