Short answer: In one randomized trial, psilocybin plus cognitive behavioral therapy led to higher quit rates than nicotine patches plus the same therapy. Among 82 adult smokers, about 40 percent in the psilocybin group were smoke free at six months with biochemical verification, versus about 10 percent in the patch group, according to a randomized trial in JAMA Network Open.
I cannot independently verify studies published after October 2024. The reported trial was small, unblinded, and relatively homogeneous, so expectations and selection could influence outcomes. These findings need replication in larger, multi site studies before drawing firm conclusions.
Bottom line: The study suggests psilocybin may outperform nicotine patches at six months within that research setting, but it does not establish a new standard of care.
Hope this helps.