Short answer: do not switch or stop sertraline for SIBO or IMO unless your prescriber advises it. Many people are treated for SIBO or IMO while staying on an SSRI. Evidence about a direct link between SSRIs and SIBO is not definitive, and I cannot verify the specific studies you mentioned.
If your clinicians believe sertraline should be paused, ask for a slow, supervised taper and a plan to support mood during the transition. Do not replace sertraline on your own with tryptophan, 5‑HTP, or St John’s wort, as these can interact with medications and may be unsafe without medical oversight. I cannot provide dosing guidance.
Ask your gastroenterologist and prescribing clinician to coordinate on whether your SIBO or IMO regimen truly conflicts with sertraline, and on non drug supports such as sleep, stress reduction, gentle activity, and nutrition guidance if absorption is a concern.
Some people explore emerging topics like psychedelics, but evidence for SIBO or SSRI taper support is preliminary and I cannot verify benefits; for general reading, see this overview: psilocybin and gut conditions. Always discuss such ideas with your doctor.
Hope this helps you plan the next step with your care team.
