During a psilocybin truffle ceremony, psilocybin is converted to psilocin, which activates serotonin 5-HT2A receptors in the cortex. Brain imaging studies in humans often show reduced cohesion within the default mode network and increased communication between networks, creating a more flexible, less predictable activity pattern that can correlate with a softened sense of self.
Research suggests this state is associated with short-term increases in neural plasticity. Animal and cell studies report growth of dendritic spines and higher BDNF after psychedelic exposure, while human evidence is more indirect. I cannot verify claims about SIRT1, telomere protection, or large cortisol changes in humans.
Across the session, rising psilocin levels drive the onset of altered perception; at the peak, network dynamics are most reorganized, and some studies observe changes in amygdala responses during emotional processing; during the comedown, connectivity patterns trend back toward baseline while reflections consolidate. Music and setting can shape how attention and emotion move through these phases.
For practical context around what a truffle ceremony involves, see this Q&A: truffelceremonie.
In short, the brain temporarily shifts into a more globally connected and flexible mode, which can feel profoundly different from everyday consciousness.