From psilocybin to psilocin
After consuming truffles, psilocybin is converted to psilocin, a molecule that resembles serotonin. Psilocin primarily activates 5-HT2A receptors in the cortex, which increases glutamate signaling and loosens the usual synchrony between brain regions. This temporary rise in network flexibility, often described as higher brain entropy, opens the door to new patterns of thinking and perception.
Perception and belief updating
Under psilocin, the brain gives less weight to rigid expectations and more weight to fresh input. This aligns with the REBUS idea, where entrenched beliefs soften and new perspectives can surface. Many people describe this as seeing familiar problems from a radically different angle, which can support cognitive and emotional reframing.
Self-referential quieting and connectivity
Activity in the Default Mode Network, a hub linked to self-talk and rumination, typically decreases. As this network quiets, communication between other brain systems often increases, which can coincide with a reduced sense of separation and a stronger feeling of connection with others and the environment.
Neuroplasticity during and after
Psilocybin is associated with markers of neuroplasticity, including increases in plasticity-related factors such as BDNF and growth of dendritic spines in key regions. This window can last days to weeks, which is why integrating insights and practicing new habits after the ceremony may help consolidate change.
Emotion and music
The amygdala, a center for threat detection, tends to be less reactive, allowing safer access to difficult emotions. Music can strongly shape the trajectory of the experience by engaging auditory and emotional networks, often making sound feel deeply embodied and guiding the emotional flow without words.
Body-brain interplay
The gut-brain axis also plays a role. Since most serotonin is produced in the gut, serotonergic shifts can influence digestion and inflammation, and some studies suggest changes in pro-inflammatory signaling. Reductions in stress physiology, including cortisol, may follow a supportive session, which can benefit sleep and overall recovery.
Practical takeaways
In short, a psilocybin truffle ceremony temporarily increases brain flexibility, eases rigid self-referential activity, and opens a plasticity window in which new insights can be integrated into daily life. For a clear community overview of what a ceremony involves and how people experience it, see this Q&A on truffle ceremonies at Tripforum.
Conclusion
What happens in the brain is a coordinated shift toward flexibility and connectivity that can reshape perception, emotion, and behavior. When followed by mindful integration, these changes may translate into lasting growth.