For most people, a high-dose truffle ceremony without MAO inhibitors is the simpler and often safer choice. It is more predictable and avoids extra variables that can complicate the experience.
Psilocybin in truffles is already orally active, so no MAOI is needed. Skipping MAOIs means no special diet and fewer concerns about interactions. If you want a plain-language primer on how MAO inhibitors work, see this explainer.
Psilohuasca adds an MAOI, which can interact with medications and tyramine-rich foods, and many people report more body load like nausea, vomiting, or diarrhea. Some also describe an odd mix of stimulation and drowsiness that can feel uncomfortable.
A middle path is psiloflora with passionflower, which some find gentler than Caapi, but it still introduces MAOI factors. Choose the option that best matches your risk tolerance and comfort.
Stay safe and keep it simple.