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Can I have a ketamine session without a prescription or referral?

In the Netherlands, you cannot have an official ketamine or Spravato session without a referral and clinical supervision. These medical treatments are only provided in recognized clinics. At Triptherapie, you can choose a non-medical option using a legal ketamine analog. This is not a medicine, so no prescription or referral is required. The focus is […]

How can Triptherapie already offer legal LSD sessions with trained therapists?

In the Netherlands, classic LSD is illegal. Triptherapie states that it stays within the law by not supplying illegal substances and by facilitating sessions with LSD-like analogs that are not explicitly scheduled, offering similar subjective effects. They emphasize harm reduction and legal compliance. I cannot verify the legal status of any specific compound, and laws […]

Does psilocybin reduce chronic cluster headache attacks via the hypothalamus?

Short answer: psilocybin might reduce chronic cluster headache attacks, and the improvement appears to track with changes in hypothalamic connectivity, but this does not prove the hypothalamus is the causal route. In a small open-label study of 10 people with chronic cluster headache, participants received three oral doses of psilocybin over three weeks. On average, […]

Does escitalopram reduce psilocybin’s negatives without reducing positives?

Short answer: In a controlled setting with healthy volunteers, short-term escitalopram pretreatment appeared to reduce psilocybin’s negative effects (like anxiety and other adverse effects) without meaningfully reducing the positive subjective effects of a 25 mg dose (study). Escitalopram did not change psilocin pharmacokinetics, and there were no observed changes in QTc intervals or circulating BDNF […]

Can you provide a guided psilocybin session at my home in Hillegom?

Yes, we can guide a psilocybin session at your home in Hillegom. Home visits in nearby towns such as Lisse, Noordwijkerhout, and Hoofddorp are also possible. Before the session we schedule a short intake to discuss intentions, preparation, and the setting. On the day itself your facilitator offers supportive guidance in a calm environment. Afterward […]

Does psilocybin reduce P300 while leaving MMN intact in auditory processing?

Yes. In a placebo-controlled, double-blind cross-over EEG study in 20 healthy volunteers given oral psilocybin (0.26 mg/kg), P300 amplitude was significantly reduced while mismatch negativity (MMN) was not reliably changed. The data also showed a decrease in N100, suggesting some impact on early perceptual processing, and the P300 reduction correlated with both subjective intensity and […]

Is psilocybin rapidly converted to psilocin with linear dose pharmacokinetics?

Yes. In healthy adults, oral psilocybin appears to be rapidly converted to psilocin, and psilocin shows approximately linear pharmacokinetics across 0.3 to 0.6 mg/kg, based on an open-label dose-escalation study (details here). In that study, intact psilocybin was not measurable in plasma or urine, indicating fast conversion. Psilocin had an average elimination half-life near 3 […]

Is a psychedelic session safe for a veteran with complex PTSD on pregabalin?

Short answer: it cannot be called safe by default. With complex PTSD and current pregabalin use, only an individualized assessment by a qualified clinician can weigh risks. I cannot verify safety for your friend online. Pregabalin may blunt or alter psychedelic effects. This can tempt dose increases, which raises the chance of adverse reactions like […]

How does MDMA affect oxytocin?

MDMA appears to amplify oxytocin signaling. Studies report increased oxytocin release after MDMA, and some evidence suggests the brain becomes more responsive to oxytocin during the experience. Oxytocin is associated with trust, bonding, empathy, and feeling safe with others. As a result, many people on MDMA describe feeling warmer, more open, and more connected. These […]

Should I do truffle therapy alone or with a group?

Go one-on-one if you want privacy, focused guidance, and a pace set entirely by you. This suits people who feel overwhelmed in groups or want space for sensitive, personal work. Choose a small private group with people you know if you value trust and shared support. Pick an open group if you want community and […]

Which Pixar movies are best to watch on a low dose of shrooms?

For a gentle, soothing watch with rich colors and calm flow, try Finding Nemo, Finding Dory, Luca, Monsters, Inc., Ratatouille, and WALL·E. These pair soft motion, friendly designs, and clear storytelling with comforting themes. If you want light introspection without heavy intensity, go for Inside Out, Inside Out 2, Soul, Toy Story 2, Cars, and […]

Is psychedelic coaching available in Amsterdam?

Yes, psychedelic coaching is available in Amsterdam. Sessions are usually offered on location, such as at your home or a rented space like an Airbnb. Availability depends on scheduling and travel distance, so it is best to plan in advance. Several facilitators who work in the Randstad can come to Amsterdam, and you can also […]