Short answer: sometimes. Available research and practitioner reports indicate the combination is not always prohibited, but the psilocybin experience is often muted or different while on an SSRI. Effects vary by person and by medication. Common approaches people consider include continuing the SSRI and accepting a likely dampened effect, tapering then waiting about five half-lives […]
FAQ
Can I safely do a psilocybin ceremony while taking citalopram?
Short answer: it is not a clear yes or no. Some people do a psilocybin ceremony while on citalopram, and responses vary. Effects can be dampened for some, while others still have a noticeable experience. I cannot verify safety for your specific situation. Key factors are your current stability, your citalopram dose, and how long […]
How do acute and chronic fluoxetine affect mice’s psychedelic response?
In male mice, a single acute dose of fluoxetine at 10 mg/kg did not change the head-twitch response to DOI, while 14 days of fluoxetine at the same dose reduced DOI sensitivity, and this reduction resolved after 14 days without the drug, according to a recent preclinical study on SSRI and psychedelic interactions. For psilocybin, […]
How strongly does selection bias affect reported benefits of psychedelics?
Selection bias can be strong. In a survey comparing psychedelic enthusiasts to a more general sample, enthusiasts reported markedly larger quality-of-life gains, with a between-group difference around d = 0.84. Importantly, this gap remained even after adjusting for mindset, setting, motivation, and personality, and group membership was the strongest predictor of reported impact. These findings […]
Do therapeutic context and support buffer stress in difficult psychedelic trips?
Short answer: partly yes. In a large survey, a therapeutic-like setting and supportive relationships were linked to weaker connections between life stress, difficult psychedelic experiences, and some negative psychological outcomes. The buffering was not universal across all outcomes. In an international online survey of 1,867 psychedelic users reported in a recent study, researchers tested whether […]
Is psychedelic therapy no better than open-label antidepressants in depression?
Short answer: not proven. A recent comparison by researchers reported no greater effectiveness for psychedelic therapy than open-label antidepressants, but it relies on indirect comparisons across separate studies and is not a head-to-head trial: see the summary here. I cannot independently verify the conclusions beyond what the authors present. Psychedelic therapy is a package of […]
What predicts psychedelic therapy success in depression, especially in-session?
In-session factors appear to be the strongest predictors of antidepressant improvement in psychedelic-assisted therapy. Emotional breakthrough, mystical or unitive qualities, and ego dissolution paired with insight or reappraisal were most often linked with larger and more durable symptom reductions. Anxiety-dominant or dysphoric states tended to coincide with smaller gains, even when overall intensity was high. […]
Are psilocybin truffles bad for your health?
Psilocybin truffles are not inherently bad for your health, but they are not risk free. Effects vary with dose, mindset, and environment, and long term outcomes are not well established. Risks can include acute anxiety or panic, nausea, confusion, and short term increases in heart rate and blood pressure. Use is generally discouraged for people […]
What sets Gijs Tecklenburg apart as a therapist and tripsitter?
Gijs Tecklenburg stands out for a calm, attentive, and deeply present way of working. He favors space over control and attunement over technique, helping clients find insight without forcing the process. His background combines many years in Dutch mental health care with extensive mindfulness work. He integrates approaches like mindfulness, ACT, breathwork, neurofeedback, and especially […]
Is psychedelic therapy right for childhood trauma and loneliness on Vyvanse?
Psychedelic therapy can help some people explore childhood-rooted loneliness and fear by bringing buried feelings to the surface in a supported setting. It is not a quick fix and it is not right for everyone. Careful screening, a legal context, and an experienced facilitator are essential. Because you use Vyvanse, extra caution is needed. Stimulants […]
What do clients say about Triptherapie therapists and tripsitters?
Client reviews on the Triptherapie forum consistently mention feeling safe, seen, and well supported during guided sessions. You can browse a broader sample of experiences in this review overview. These are client reports and I cannot verify individual outcomes. Marcel is often described as calm, professional, and empathic, creating trust for both individuals and couples […]
Is it safe to mix ADHD meds with psilocybin, MDMA, LSD, ketamine, or ayahuasca?
Short answer: mixing prescription ADHD stimulants (like lisdexamfetamine, methylphenidate, or dexamfetamine) with psychedelics can raise the chance of overstimulation, anxiety, and cardiovascular strain. Risk varies by substance and setting. Highest concern is ayahuasca, because it contains MAO‑A inhibitors. Stimulants combined with MAOIs are widely warned against in official product information (see the Dutch SmPC for […]
