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Does psilocybin reduce P300 while leaving MMN intact in auditory processing?

Yes. In a placebo-controlled, double-blind cross-over EEG study in 20 healthy volunteers given oral psilocybin (0.26 mg/kg), P300 amplitude was significantly reduced while mismatch negativity (MMN) was not reliably changed. The data also showed a decrease in N100, suggesting some impact on early perceptual processing, and the P300 reduction correlated with both subjective intensity and […]

Is psilocybin rapidly converted to psilocin with linear dose pharmacokinetics?

Yes. In healthy adults, oral psilocybin appears to be rapidly converted to psilocin, and psilocin shows approximately linear pharmacokinetics across 0.3 to 0.6 mg/kg, based on an open-label dose-escalation study (details here). In that study, intact psilocybin was not measurable in plasma or urine, indicating fast conversion. Psilocin had an average elimination half-life near 3 […]

Is a psychedelic session safe for a veteran with complex PTSD on pregabalin?

Short answer: it cannot be called safe by default. With complex PTSD and current pregabalin use, only an individualized assessment by a qualified clinician can weigh risks. I cannot verify safety for your friend online. Pregabalin may blunt or alter psychedelic effects. This can tempt dose increases, which raises the chance of adverse reactions like […]

How does MDMA affect oxytocin?

MDMA appears to amplify oxytocin signaling. Studies report increased oxytocin release after MDMA, and some evidence suggests the brain becomes more responsive to oxytocin during the experience. Oxytocin is associated with trust, bonding, empathy, and feeling safe with others. As a result, many people on MDMA describe feeling warmer, more open, and more connected. These […]

Should I do truffle therapy alone or with a group?

Go one-on-one if you want privacy, focused guidance, and a pace set entirely by you. This suits people who feel overwhelmed in groups or want space for sensitive, personal work. Choose a small private group with people you know if you value trust and shared support. Pick an open group if you want community and […]

Which Pixar movies are best to watch on a low dose of shrooms?

For a gentle, soothing watch with rich colors and calm flow, try Finding Nemo, Finding Dory, Luca, Monsters, Inc., Ratatouille, and WALL·E. These pair soft motion, friendly designs, and clear storytelling with comforting themes. If you want light introspection without heavy intensity, go for Inside Out, Inside Out 2, Soul, Toy Story 2, Cars, and […]

Is psychedelic coaching available in Amsterdam?

Yes, psychedelic coaching is available in Amsterdam. Sessions are usually offered on location, such as at your home or a rented space like an Airbnb. Availability depends on scheduling and travel distance, so it is best to plan in advance. Several facilitators who work in the Randstad can come to Amsterdam, and you can also […]

How does an MDMA session work?

An MDMA-supported session is typically a guided process that combines your inner experience with a safe, structured setting. People often report feeling more open, less self-critical, and more connected, which can make it easier to explore difficult memories or patterns without feeling overwhelmed. The flow usually has three parts: preparation to set intentions and discuss […]

Where can I find reputable guided psychedelic retreats in the Netherlands?

Reputable guided psychedelic retreats in the Netherlands focus on solid preparation, skilled facilitation, and thoughtful integration. Settings range from yurt-based ceremonies with music and ritual to small, nature-based programs that include screening, a structured session, and aftercare. If you want a quieter natural environment with a full guided trajectory and the option to stay overnight, […]

Can I use MDMA for PTSD?

Short answer: do not use MDMA on your own for PTSD. MDMA is a controlled substance in most countries and, outside approved clinical trials, it is not an authorized PTSD treatment. There is ongoing research into MDMA-assisted therapy, but it takes place only in regulated settings with trained professionals. Self-medicating or working with underground providers […]

Can a psychedelic session help with chronic insomnia and anxiety in older adults

Psychedelic sessions may help some older adults feel less anxious and mentally overactive, which can indirectly support sleep. Evidence specific to chronic insomnia in older adults is still limited, and results vary by person. I cannot verify that it will help in your case. Age by itself is not an automatic barrier, but careful screening […]

Do you need a tripsitter for your first psilocybin truffle experience?

You do not strictly need a tripsitter for a first psilocybin truffle experience, but having a sober, trusted sitter or professional guide can add safety, reassurance, and focus so you can engage with the experience more calmly. A sitter is especially helpful if you feel anxious, are new to altered states, or are in an […]